Hyperbilirubinemia workup in adults hyperbilirubinemia differential diagnosis. Burghardt km, avinashi v, kosar c, et al. The roles of mrp2, mrp3, oatp1b1, and oatp1b3 in conjugated hyperbilirubinemia. Evaluating elevated bilirubin levels in. An algorithmic approach to the evaluation of jaundice in adults. Jaundice and asymptomatic hyperbilirubinemia are common clinical problems that can be caused by a variety of disorders, including bilirubin overproduction.
Bilirubin is the normal by. This type of hyperbilirubinemia results from overproduction of bilirubin, due, for example, to hemolysis, impaired uptake, or abnormal conjugation. More commonly, the bilirubin in asymptomatic hyperbilirubinemia is composed primarily of unconjugated bilirubin. Unconjugated hyperbilirubinemia symptoms, causes, diagnosis, and treatment information for. Of patients with unconjugated hyperbilirubinemia, there is impaired clearance of bromosulfophthalein, indocyanine green, and free fatty acid, suggesting an abnormality in hepatic uptake, transport, or both. Hyperbilirubinemia can be caused by conditions.